Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Age‐Related Macular Degeneration (AMD) is a leading cause of vision loss among older adults. The role of serum lipid profiles in the pathogenesis of AMD has been of increasing interest. This study aimed to investigate the association between serum lipid profiles and the presence of AMD in a cross‐sectional cohort. A total of 100 participants, consisting of 60 AMD patients and 40 age‐matched controls, were enrolled. The study assessed serum levels of total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C) and triglycerides (TG). Logistic regression analysis was performed to evaluate the association between these lipid parameters and the risk of AMD. The AMD group exhibited significantly higher levels of TC (220.3±35.7 mg/dL) and LDL‐C (140.2±25.6 mg/dL) compared to the control group (195.6± 28.9 mg/dL for TC and 120.1±20.4 mg/dL for LDL‐C), with p‐values < 0.01. HDL‐C levels were significantly lower in the AMD group (44.8±10.2 mg/dL) than in controls (52.1±11.3 mg/dL, p < 0.05). No significant difference in TG levels was observed between groups (p>0.05). Logistic regression revealed an increased risk of AMD with higher TC and LDL‐C levels, while lower HDL‐C levels were associated with reduced AMD risk. The study highlights a significant association between elevated serum lipid levels and AMD, suggesting that lipid management could be pivotal in AMD prevention and treatment.
How to cite this article:
Beatric Choppara, Irigu Vijay Kumar and Aradhana Badam. Investigating the Association Between Serum Lipid Profiles and Age‐Related Macular Degeneration: A Cross‐Sectional Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.1.4
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.1.4