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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Study of Clinicopathological, Autopsy and Histopathological Correlation of Primary and Metastatic Lung Malignancies

Anjali Mahajan, Poonam G. Lahane, Disha Sorde, Ramesh Pawar, Nilesh K. Lomte and Shital Solanke
Page: 581-586 | Received 19 May 2024, Published online: 22 Jul 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.8.581.586

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Abstract

Lung cancer is currently the most frequently diagnosed major cancer in the world and the most common cause of cancer mortality worldwide. Present study was aimed to study clinicopathological, autopsy and histopathological correlation of primary & metastatic lung malignancies at a tertiary hospital. Present study was single‐center, cross sectional, observational study, conducted in patients of Age >20 years, either gender, known or suspected cases of malignancies involving lungs and incidentally found cases at autopsy. Out of 51 cases, 24 (47.05%) were primary tumours of lung. And 27 (52.9%) were metastatic tumours. Mean age of presentation in primary lung cancer cases is 53.4 yrs. 35 were males (68.6 %) and 16 were females (31.3 %). Along with 10 cases (41.67%) with history of smoking, 9 cases (37.5%) were observed with no addiction, followed by 3 cases (12.5%) of chronic alcoholism and 2 cases (8.33%) of chronic tobacco chewer. Histopathologically, adenocarcinoma was found to be the most common type of primary lung cancer (41.67%) in our study followed by squamous cell carcinoma (24%). Small cell carcinoma was found in 16.67% cases, while single case of Adenosquamous and Large cell carcinoma comprising 4.16% was observed. Out of 24 cases in 16 cases there was evidence of metastasis, that to most commonly to Hilar LN in 8 cases i.e. 33.3% followed by Liver (7 cases i.e. 29.16%) and Adrenals (4 cases i.e. 16.6%). Majority of patients i.e. n=22 is died due to Respiratory failure followed by Cachexia (n=13) and Disseminated malignancy (n=9). From the present study we conclude that secondary Lung malignancies outnumber the primary. Majority cases of lung cancer were misdiagnosed clinically as TB. Our study also reflects the global trend of rise in adenocarcinoma histology.

How to cite this article:

Anjali Mahajan, Poonam G. Lahane, Disha Sorde, Ramesh Pawar, Nilesh K. Lomte and Shital Solanke. Study of Clinicopathological, Autopsy and Histopathological Correlation of Primary and Metastatic Lung Malignancies.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.8.581.586
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.8.581.586