Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Myasthenia gravis is an autoimmune postsynaptic disorder affecting the neuromuscular junction of skeletal muscle. It is characterized by a wide variety of signs and symptoms. Ocular Myasthenia is a form of the disease in which the disease is limited to the ocular muscles. Ocular myasthenia is diagnosed by typical clinical features and response to neostigmin. A large number of tests and investigations like Icepack test, Repetitive nerve stimulation, and Single fiber EMG etc are available for the diagnosis. This is a cross sectional record based study using the copies of discharge cards of patients with symptoms suggestive of ocular myasthenia admitted in neurology ward and outpatient ticket details of the similar patients attending in the neurology OPD from June 2020(01/06/2020 to June 2023 (01/06/2023). Patients were divided into two groups. (1) Patients who had ptosis, ocular symptoms,signs and clinical features suggestive of ocular myasthenia and positive response to neostigmin. Patients who had ptosis and ocular findings, but without clinical featuresof myasthenia and without any response to neostigmin. Patients in both groups were subjected to Repetitive Nerve stimulation test. Both patent groups were further followed upwith relevant investigations. Ocular myasthenia is more common in young females, there is a single peak of incidence (30‐40yrs) in the females and 60‐70 yrs in males. Diurnal variation and fatigability were hallmarks of the disease .Ptosis followed by diplopia were the common symptoms. Repeptitive nerve stimulation is a useful test which can be done as an outpatient procedure for the diagnosis of ocular myasthenia. The sensitivity and specificity of the RNS test in our study was 90.00% & 94.29% respectively (with 95% CI ). The accuracy of the test was 92.14% .All this values are significant when compared to other studies. RNS has to be used judiciously and the procedure should be planned meticulously to produce better yields.
How to cite this article:
N. Byju, J.P. Padma, C. Susha and T.S. Sudhi Raj. Repetitive Nerve Stimulation (RNS) As a Tool in the Diagnosis of Ocular Myasthenia‐A Study from A Tertiary Care Centre in India.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.7.489.495
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.7.489.495