Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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A Study on eGFR and Its Relation to HbA1c and Urinary Albumin‐Creatinine Ratio in Type 2 Diabetes Mellitus Patients
Jugnu Kishore, Papu Kumar Shah, Roshan Prakash Yadav, Navin Kumar Sinha and Uday Kumar
Page: 565-569 | Received 18 May 2024, Published online: 26 Jun 2024
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Abstract
Diabetic nephropathy is a persistent micro vascular complication arising from poorly controlled diabetes mellitus (DM), often culminating in end‐stage renal disease (ESRD). Two early indicators of renal impairment are micro albuminuria (MA) and glomerular filtration rate (GFR). Renal function can be more reliably assessed using the urinary albumin‐creatinine ratio (ACR) in a spot urine sample. Additionally, GFR can be estimated using formulae based on a single blood sample for serum creatinine (S.Cr), such as the Cockcroft‐Gault (C‐G) formula, which correlates well with CCR. The objective of this study was to investigate the correlation between HbA1c and urinary ACR and estimated GFR (eGFR) in individuals with Type 2 DM. A cross‐sectional study evaluated fifty 78 known Type 2 DM patients aged 40‐60 years. Participants were categorized based on HbA1c levels (<8% and >8%), duration of DM (>5 years and <5 years), and blood pressure status (normotensive or hypertensive). Fasting blood sugar (FBS), S.Cr, and urinary albumin and creatinine levels were measured. eGFR and urinary ACR were subsequently calculated. Results were anlysed with a p‐value of <0.05 considered significant using SPSS version 18.0. A significant difference in S.Cr and HbA1c was observed between groups with HbA1c levels <8% and >8%. Diastolic blood pressure (DBP) was notably elevated in hypertensive Type 2 DM patients. The duration of DM did not significantly correlate with renal functional parameters. S.Cr and urinary ACR showed a significant positive correlation with HbA1c levels >8%, and a significant correlation with ACR, but not S.Cr, was noted in subjects with HbA1c levels <8%. Elevated HbA1c is associated with increased urinary ACR. Monitoring urinary ACR is recommended for risk assessment in Type 2 DM patients with elevated HbA1c levels.
How to cite this article:
Jugnu Kishore, Papu Kumar Shah, Roshan Prakash Yadav, Navin Kumar Sinha and Uday Kumar. A Study on eGFR and Its Relation to HbA1c and Urinary Albumin‐Creatinine Ratio in Type 2 Diabetes Mellitus Patients.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.565.569
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.565.569