Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Sickle cell disease (SCD) is a chronic hemolytic condition marked by the presence of crescent‐shaped red blood cells. Abdominal pain is a frequent presenting symptom in adults with SCD. Among non‐crisis patients, it is estimated that one‐third of individuals with homozygous SCD who experience chronic recurrent epigastric pain exhibit endoscopic evidence of peptic ulcer disease. This study aimed to analyze the incidence and management of acid peptic disorders among SCD patients. A prospective study was conducted involving 108 homozygous SCD patients. Each patient underwent upper gastrointestinal endoscopy (UGIE) with gastric antral biopsy and a rapid urease test (RUT). Patients with Helicobacter pylori infection were treated with a 14‐day regimen of triple therapy for H. pylori and were re‐evaluated six weeks after starting treatment with repeat UGIE and RUT. Among the SCD cases, patients had duodenal ulcers, a significantly higher incidence compared to gastric ulcers. Additional findings included gastroesophageal reflux disease and gastritis. Approximately 94% of patients tested negative for H. pylori on the RUT after completing the medication regimen. A substantial proportion of SCD patients presenting to surgical outpatient and inpatient departments suffer from acid peptic disorders. Conservative treatment combined with lifestyle modifications can effectively alleviate the symptoms of acid peptic disease.
How to cite this article:
Rinku Bhagora, Sakshi Chaurasia, Shilpi Singh and Megha Goswami. Acid Peptic Disorders in Sickle Cell Disease: Incidence and Management Strategies.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.537.540
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.537.540