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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Electrolyte Disturbances and Their Significance in Late Stage Chronic Kidney Disease: A Cross‐Sectional Study

Damor Manjulaben Kanabhai, Hemali Jha, Riddhi Patel and Vishwakarma Nirali Rakeshkumar
Page: 529-532 | Received 30 Apr 2024, Published online: 05 Jun 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.6.529.532

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Abstract

The kidneys play a vital role in maintaining electrolyte and acid‐base balance. Progressive loss of kidney function inevitably leads to electrolyte disturbances, which adversely affect patient outcomes. As chronic kidney disease (CKD) becomes increasingly prevalent worldwide, this study aimed to evaluate serum electrolyte variations and their significance in pre‐dialysis and dialysis patients with CKD. This cross‐sectional study was conducted including 156 participants aged 30‐85 years. The cohort comprised 78 CKD patients in the pre‐dialysis stage and 78 in the dialysis stage. Each participant's medical history was thoroughly documented according a pre‐designed proforma, peripheral venous blood samples (5 mL) were collected and analyzed biochemically using automated chemistry analyzer and immunoanalyzer. An independent sample t‐test was employed to compare serum electrolyte levels between pre‐dialysis and dialysis stages. Data analysis was done using SPSS 20.0. Most patients maintained normal serum levels of potassium, chloride, sodium and calcium. However, the dialysis group exhibited significantly higher serum phosphate and serum calcium levels compared to the pre‐dialysis group (P<0.05). No significant differences were observed for sodium, bicarbonate, chloride and potassium levels between the groups. Electrolyte disturbances in CKD patients vary based on medical management, diet, comorbidities and lifestyle. Variations in serum phosphate and calcium levels were significant between pre‐dialysis and dialysis patients. Careful monitoring and prediction of electrolyte disturbances can help delay CKD progression and reduce associated complications.

How to cite this article:

Damor Manjulaben Kanabhai, Hemali Jha, Riddhi Patel and Vishwakarma Nirali Rakeshkumar. Electrolyte Disturbances and Their Significance in Late Stage Chronic Kidney Disease: A Cross‐Sectional Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.529.532
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.529.532