Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Crush smear cytology, is a useful adjunct to conventional histopathology for diagnosis of Gastrointestinal (GI) malignancies as it enhances cell yield and expedites diagnostic work up. Aim of our study is to determine the diagnostic accuracy of crush smear cytology by comparing with histopathology in GI malignancies. In this prospective, cross sectional analytical study, Crush smear slides and formalin preserved tissue samples of 180 cases obtained during GI endoscopic or colonoscopic procedures, were processed for cytology and Histopathology (HP) study. Relevant clinical history and endoscopic finding of each patient was obtained in standard format. The diagnosis on crush smear cytology was correlated with histopathological diagnosis. SPSS Statistics 24.0 has been used. Categorical variables studied by using frequency procedure, diagnostic efficacy of crush smear cytology have been done by using diagnostic test evaluation calculator ‐ MEDCALC software. Out of 180 cases, 90 (50%) cases were reported as malignant on cytology whereas 95 (52.77%) cases on histopathology. 6 cases of malignancy were reported as negative (false negative) and 14 cases of non‐ malignant lesions were reported positive (false positive) on cytology smears. Basing on the above findings, Sensitivity, Specificity, PPV, NPV and diagnostic accuracy were calculated to be 93.68%, 83.53%, 86.41%, 92.21% and 94.82%, respectively. Crush smear cytology gives a high diagnostic yield in GI malignancy. Hence, cytology diagnosis saves time and gives proper timely feedback to the gastroenterologists for early management of the patients.
How to cite this article:
Jena Archana, Pattnaik Kaumudee, Pradhan Pranati and S. Das Haribhakti. Diagnostic Accuracy of Crush Smear Cytology in Gastrointestinal Malignancy.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.438.444
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.438.444