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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Effect of 6 Weeks Therapy With Vitamin B12 and Folic Acid and on Homocysteine Levels in Pregnant Women With Unexplained Recurrent Pregnancy Loss

Dharmveer Sharma, Neelam Singh Raghuwanshi, Megha Goswami and Janki M. Kanani
Page: 428-431 | Received 11 Apr 2024, Published online: 20 May 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.6.428.431

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Abstract

Recurrent pregnancy loss that occurs spontaneously can impose both physical and emotional strains on couples. Identified causes often involve uterine anomalies, endocrine irregularities, autoimmune disorders, and genetic factors. Despite thorough evaluation, around half of the cases still lack a clear explanation. This study was designed to evaluate the levels of serum homocysteine, Vitamin B12 and serum Folic Acid in mothers experiencing recurrent pregnancy loss. A prospective study was conducted involving 123 pregnant mothers with a history of unexplained recurrent pregnancy loss (RPL). The study aimed to assess serum homocysteine, Vitamin B12 and serum Folic Acid levels in these mothers. Patients with hyperhomocysteinemia (>12 micromol/l) were treated with folic acid and vitamin B12 supplements for 6 weeks, regardless of their biochemical values of vitamin B12 and folic acid. Serum levels of homocysteine, folic acid and vitamin B12 were reassessed post‐treatment. Results showed that after vitamin supplementation, more than 75% of patients exhibited a reduction in serum homocysteine levels, while rest continued to have hyperhomocysteinemia. Similarly, the mean serum vitamin B12 level increased significantly post‐supplementation. Additionally, the mean serum folic acid level rose significantly after supplementation. Our findings indicate an association between RPL with hyperhomocysteinemia and folic acid and vitamin B12 deficiency. Vitamin supplementation effectively reduced homocysteine levels in patients with hyperhomocysteinemia.

How to cite this article:

Dharmveer Sharma, Neelam Singh Raghuwanshi, Megha Goswami and Janki M. Kanani. Effect of 6 Weeks Therapy With Vitamin B12 and Folic Acid and on Homocysteine Levels in Pregnant Women With Unexplained Recurrent Pregnancy Loss.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.428.431
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.428.431