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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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An Observational Study Assessing Vitamin D Levels and Relationship Between Insulin Resistance with Vitamin‐D Status among Individuals with Pre‐Diabetes and Diabetes

Geetika Sura, Matcha Sridevi and Metta Madhuri
Page: 410-414 | Received 25 Mar 2024, Published online: 13 May 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.6.410.414

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Abstract

The aim of the present study is to compare Vit D levels between the normals, pre‐diabetics and diabetics and study the relationship between insulin resistance and vitamin‐D status among individuals with pre‐diabetes and diabetes. It was a hospital based cross‐sectional study done in multiple tertiary care Hospitals over a period of one year . The study subjects included age and sex matched 300 subjects who were divided into three groups‐100 Normal subjects, 100 pre‐diabetic subjects and 100 type 2 diabetic subjects. Fasting insulin levels and insulin resistance (HOMA2 IR) were also increased very significantly in pre diabetics and diabetics as compared to normals (p<0.001) and in diabetics as compared to pre diabetics. 25 OH vitamin‐D levels were significantly decreased (p<0.001) in pre diabetics and diabetics as compared to normals (p<0.001). There was no significant change in 25OH Vit D levels between pre diabetics and diabetics. There was no significant difference in HOMA2‐ß (beta cell mass) between the groups. There was a strong negative correlation between 25 OH vitamin‐D and HOMA 2 IR in diabetics. Similar strong correlation was found between 25 OH vitamin‐D and fasting insulin levels in diabetics (r= ‐0.52) and pre diabetic (r= ‐0.76). 25 OH vitamin‐D had strong negative correlation with FBS in diabetics (r= ‐0.58) and pre diabetic (r= ‐0.66), systolic BP(r = ‐0.44) and diastolic BP (‐0.46) in diabetics. vitamin‐D deficiency is common in pre diabetic state and subjects having severe vitamin D deficiency (<10 ng/ml), had the worst insulin resistance. This study results help in strongly proposing vitamin D levels as an early marker for diabetes and help in recommending vitamin D to be prescribed in the pre diabetic stage to prevent Diabetes in later stage of the life.

How to cite this article:

Geetika Sura, Matcha Sridevi and Metta Madhuri. An Observational Study Assessing Vitamin D Levels and Relationship Between Insulin Resistance with Vitamin‐D Status among Individuals with Pre‐Diabetes and Diabetes.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.410.414
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.410.414