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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Study of Microbiological Pattern and Antimicrobial Resistance Pattern in Patients With Ventilator Associated pneumonia at a tertiary hospital

Anushree S. Gaigawale, Meena Mishra and Rajendra Surpam
Page: 390-396 | Received 20 Mar 2024, Published online: 10 May 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.6.390.396

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Abstract

Ventilator associated pneumonia (VAP) occurs frequently and is associated with significant morbidity in critically ill patients. A knowledge of antibiotic susceptibility pattern will avoid irrational use of antibiotics in order to control the spread of infection and for proper management of VAP. Present study was aimed to study microbiological pattern and antimicrobial resistance pattern in patients with ventilator associated pneumonia at a tertiary hospital. Material and Present study was hospital based, prospective, observational study, conducted in patients >18 years, of either gender, who were on mechanical ventilation for more than 48 hours in ICU, who had Clinical Pulmonary Infection Score (CPIS) values (>6) including fever greater than 38°C, leucocytosis, oxygenation, progressive radiographic infiltrate and tracheal aspirate culture result. In present study, 153 clinically suspected patients of VAP were studied. Male to female ratio was found to be 1.55:1. Maximum number of cases put on mechanical ventilation had sepsis (37.90%) followed by miscellaneous conditions (22.87%), encephalopathy/ hemiplegia / hemiparesis (9.15%), head injury (7.84%), organo‐phosphorous poisoning (7.19%), diabetic complications (5.88%). Out of 153 clinically suspected cases, 59 were found culture positive VAP. Out of 21 early onset VAP cases maximum organisms isolated were Pseudomonas aeruginosa (30.43%) followed by Acinetobacter species (17.39%), Klebsiella pneumoniae (17.39%), Escherichia coli 3 (13.04%) and Enterobacter species (4.35%). Among the Gram positive cocci, 2 (08.70%) isolates Methicillin Sensitive Staphylococcus aureus and Enterococcus faecalis each were isolated. Out of 38 late onset VAP cases maximum organisms isolated were of Pseudomonas aeruginosa (26.19 %) followed by Acinetobacter species (23.81%), Klebsiella pneumoniae (19.05%), Escherichia coli (14.28%). Ventilator‐associated pneumonia complicates the prognosis of patients receiving mechanical ventilation.

How to cite this article:

Anushree S. Gaigawale, Meena Mishra and Rajendra Surpam. Study of Microbiological Pattern and Antimicrobial Resistance Pattern in Patients With Ventilator Associated pneumonia at a tertiary hospital.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.390.396
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.390.396