Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Hemodialysis is associated with development of pulmonary hypertension (PH). However, maintenance dialysis has extended the lives of hundreds of thousands of patients with CKD worldwide. It is important to detect the presence of pulmonary hypertension among patients undergoing hemodialysis, this is because CKD per se has increased cardiovascular morbidity and mortality; but the genesis of pulmonary hypertension as a consequence of hemodialysis (a mode of RRT) will have summation effect on the cardiovascular complications, thus reducing the life span of these patients. Further, detecting the presence of PAH among patients secondary to RRT who are due for transplantation will guide us about the overall prognosis in the post‐transplant period. The data regarding PAH among patients with long term hemodialysis from India is sparse; hence this study was conducted with the objectives to determine the prevalence of pulmonary hypertension and to determine the factors predisposing to pulmonary hypertension among non‐dialysis and dialysis dependent chronic kidney disease patients. Case Control study was be conducted among 100 non‐dialysis and 100 dialysis dependent chronic kidney disease patients at Department of Nephrology, Mysore Medical College and Research Centre, Mysuru during July 2023 to December 2023. CKD Patients undergoing dialysis, aged >18 years, Chronic kidney disease stage 1‐4 and Chronic kidney disease stage 5 (NDD and Dialysis Dependent). CKD patients receiving conventional management. Data was collected using pre‐designed Proforma consisting of demographic profile, clinical profile, investigation profile and dialysis profile. Chronic kidney disease staging was based on the GFR values that is obtained by CKD‐EPI formula. Chi‐square test and ANOVA Test was used as test of significance. p value <0.05 was considered as statistically significant. Majority of cases were in the age group 41‐50 years (26%) and majority of controls were in the age group 61‐70 years (28%), majority of subjects were males in both groups, most common complication in both groups was Diabetes with Hypertension. Among cases, 94% were undergoing Hemodialysis and 6% were undergoing peritoneal dialysis. On 2D ECHO, in cases, 80% had Pulmonary HTN, 10% had Concentric LVH and in Controls, 9% had Pulmonary HTN, 30% had Concentric LVH. CKD patients on Dialysis had significantly higher percentage of Pulmonary HTN compared to CKD patients without Dialysis. Mean duration of Dialysis among subjects with Mild Pulmonary HTN was 14.35 ± 6.4 months, among subjects with moderate Pulmonary HTN was 23.85 ± 12.56 months and among subjects with severe Pulmonary HTN was 25.00 ± 14.5 months. From the study it was found that prevalence of pulmonary hypertension is high among patients on dialysis than those on conservative management. Among dialysis group, hemodialysis patients had high prevalence as compared to peritoneal dialysis (PD).
How to cite this article:
K. Srinivas, V. Ranjith and S.R. Shalini. Study of Prevalence of Pulmonary Hypertension Among Non‐Dialysis and Dialysis Dependent Chronic Kidney Disease Patients.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.349.353
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.349.353