Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Prevention of Surgical Site Infection in Gustilo‐Anderson Open Type IIIA and IIIB Fractures Using Antibiotic Laden Bio‐Absorbable Calcium Sulfate Granules an Observational Study
B.S. Gokul, M. Mruthyunjaya and T. Adarsh
Page: 316-320 | Received 17 Mar 2024, Published online: 08 May 2024
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Abstract
Open fractures are associated with a high infection rate and varying degrees of soft tissue and bone loss. Local antibiotics delivered through a carrier can provide high concentration of antibiotics locally at the wound site with minimal systemic toxicity. Calcium sulfate is a bio‐absorbable bone graft substitute that can also act as anosteoconductive material to hasten bone healing. This study aims to evaluate the outcome of antibiotic‐laden calcium sulfate granules in the primary prevention of infections in Gustilo Anderson open type III‐A and III‐B fractures of long bones. A prospective clinical observational study was conducted on 50 patients, who underwent surgery for Gustilo Anderson open type IIIA and IIIB fractures. Fractures were treated with thorough wound debridement followed with an appropriate choice of skeletal fixation. Vancomycin laden calcium sulfate beads prepared on site under aseptic precautions and were placed into the wound and areas of bone defects at the time of the surgical procedure. Patients were followed up for any signs of surgical site infection post‐operatively and time taken for fracture healing up to one year. The complications related to the procedure were analyzed. A total of 41 (82%) patients showed no signs of infection at the wound site. 9 (18%) patients developed discharge from the wound site which was positive for pathogenic bacteria. All the fractures showed signs of fracture union between 6‐9 months. Antibiotic‐laden calcium sulfate is a safe and effective mode of delivering a high concentration of antibiotics locally for the primary prevention of infections in Gustilo‐Anderson type IIIA and IIIB open fractures. Calcium sulfate also helps in the formation of callus due to its osteoconductive capability. Unlike polymethyl methacrylate, due to its bio‐absorbable nature, it does not need second surgery for the removal of beads. The other advantage of calcium sulphate is even heat labile antibiotics can be mixed with it to prevent infection. There were no serious complications related to its use.
How to cite this article:
B.S. Gokul, M. Mruthyunjaya and T. Adarsh. Prevention of Surgical Site Infection in Gustilo‐Anderson Open Type IIIA and IIIB Fractures Using Antibiotic Laden Bio‐Absorbable Calcium Sulfate Granules an Observational Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.316.320
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.316.320