Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Recurrent implantation failure (RIF) is a significant challenge in reproductive medicine, affecting approximately 10‐15% of couples undergoing assisted reproductive techniques. Despite various factors being implicated, the exact cause of RIF remains elusive. This study investigates the potential immunomodulatory role of Alpha thymosin, a small protein secreted by the thymus gland, in improving implantation success rates. The study involved 14 participants at the International Fertility Centre, New Delhi, who had a history of RIF. Participants received 3.2 mg of Alpha thymosin divided over two doses at the beginning of their menstrual cycle, with an additional dose prior to embryo transfer. Data collection and analysis were performed using SPSS version 26, focusing on associations between treatment and pregnancy outcomes. Of the 14 participants, 64.3% tested positive for serum beta HCG post‐treatment, with 88.9% of these showing cardiac activity in ultrasounds. Statistical analysis revealed no significant correlation between Alpha thymosin administration and serum progesterone levels or patient demographic variables (age and BMI). Alpha thymosin may enhance the uterine environment's receptivity to embryo implantation through immunomodulation. However, given the small sample size and exploratory nature of this study, further research, including randomized controlled trials, is necessary to conclusively determine its efficacy.
How to cite this article:
Anu Hirachan and Rita Bakshi. Enhancing Embryo Implantation Success: The Role of Alpha Thymosin in Modulating Immune Response in Recurrent Implantation Failure.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.6.306.310
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.6.306.310