Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Hemoglobinopathies encompass a diverse group of inherited disorders affecting hemoglobin production and function, constituting the most prevalent single‐gene disorders in humans with varying global frequencies. Pregnancy in women with sickle cell disease can elevate the risks of maternal and perinatal mortality. High‐Performance Liquid Chromatography (HPLC) offers advantages over routine Hemoglobin electrophoresis by accurately identifying and quantifying abnormal hemoglobin variants, thus serving as a reliable tool for early detection and management of thalassemia and abnormal hemoglobin variants. This observational study was conducted on pregnant women attending an Indian medical college and hospital during various gestational months. All pregnant women were counselled and offered screening for hemoglobinopathies following informed consent. Among antenatal women with hemoglobinopathy, more than 90% were anemic, while the rest were not anemic. In the normal group, more than 70% were anemic and rest were not anemic, demonstrating a significantly higher prevalence of anemia among hemoglobinopathy cases. Specifically, more than 90% of antenatal women with sickle cell disorder were anemic. Out of total women with hemoglobinopathy, 93.75% were anemic. Most hemoglobinopathy cases (about 77%) attended antenatal check‐ups after 28 weeks of gestation. In contrast, about 65% of the normal group attended antenatal check‐ups after 28 weeks. Hemoglobinopathies significantly impact pregnancy, leading to maternal morbidities such as pre‐eclampsia, preterm labor, urinary tract infection, asymptomatic bacteriuria, antepartum hemorrhage and neonatal morbidities including low birth weight, fetal growth restriction, neonatal intensive care unit (SNCU) admission rates and neonatal mortality.
How to cite this article:
Sangeeta Dudve, Avishesh Kumar Singh, Girish Ramesh Rane and Himani Rai. Impact of Hemoglobinopathies on Fetomaternal Outcome: An Outcome Assessment Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.5.665.669
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.5.665.669