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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Impact of Vitamin D Status on Psoriasis Disease Activity: A Case Control Study from Central India

Sandeep Sharma, Shyam Govind Rathoriya, Rochit Singhal, Vaishali Singh, Amardeep Malviya and Prerna Sharma
Page: 381-385 | Received 20 Aug 2024, Published online: 28 Nov 2024

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https://doi.org/10.36478/makrjms.2024.12.381.385

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Abstract

Psoriasis is known as a chronic immune‐mediated inflammatory skin condition with well‐defined erythematous plaques covered with silvery white scales. In 2014, the World Health Organization recognized psoriasis as a serious noncommunicable disease and pointed out the distress associated with mis diagnosis, inadequate treatment and the indictment of the disease. Vit D modulates the immune system and reduces the inflammation in psoriasis. Addressing vitamin D deficiency is crucial component of psoriasis severity and its management and present study will be helpful for this less explored interrelation. A total of 100 patients presenting to dermatology OPD with psoriasis were studied. Also 100 healthy controls from the hospital were also enrolled. Detailed history was taken and clinical examination of psoriasis cases was done. The degree of the illness was determined using the Psoriasis Area Severity index (PASI) and body surface area (BSA). All cases and controls were subjected to routine laboratory investigations and serum vitamin D (25‐hydroxyvitamin D) levels. Our study showed that the max. number of patients of psoriasis belonged to the 41‐50 years old age group (M: F‐1.7). 46% of psoriasis cases had a vitamin D deficiency. In our study, we observed a significant correlation between low serum 25(OH) D level and PASI score, defining the severity of psoriasis. Our study shows that vitamin D deficiency is strongly related to psoriasis disease activity. Maintenance of serum 25‐hydroxy vitamin D levels above 30ng/ml could contribute to a better outcome in psoriasis.

How to cite this article:

Sandeep Sharma, Shyam Govind Rathoriya, Rochit Singhal, Vaishali Singh, Amardeep Malviya and Prerna Sharma. Impact of Vitamin D Status on Psoriasis Disease Activity: A Case Control Study from Central India.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.381.385
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.381.385