Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Early detection of chromosomal anomalies is crucial for effective prenatal This study evaluated the combined utility of nuchal translucency (NT), free beta‐human chorionic gonadotropin (free ß‐hCG) and pregnancy‐associated plasma protein A (PAPP‐A) in predicting chromosomal abnormalities. A total of 143 pregnant women were approached, with 134 participating in the study. Screening was performed using NT, free ß‐hCG and PAPP‐A levels at 11‐13.6 weeks of gestation. Participants were stratified into risk categories based on screening outcomes and chromosomal anomalies were confirmed through diagnostic testing. Chromosomal anomalies were detected in 4 fetuses (2.98%). Increased NT measurements and abnormal free ß‐hCG levels were significant predictors of chromosomal anomalies. The combined screening method had a sensitivity of 51.7% and a specificity of 100.0%. The area under the curve (AUC) was 0.64, suggesting a high predictive value for identifying chromosomal anomalies. The combination of NT, free ß‐hCG and PAPP‐A provides a valuable tool for early screening of chromosomal anomalies, with high specificity and moderate sensitivity.
How to cite this article:
Krati Sahu, Shruti Paliwal and Shweta Bhandari. Assessment of Chromosomal Anomaly Risk in Foetuses Using Nuchal Translucency Scan, Free Beta‐HCG and PAPP‐A Levels in the First Trimester.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.376.380
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.376.380