Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Efficacy of Clonidine (30μg) and Midazolam (2mg) as Intrathecal Adjuvants to Bupivacaine on Block Characteristics and Post‐Operative Analgesia
R. Thanuja, T.K. Haridadeeswaran, P.S. Kalesh and C. Lakshmi
Page: 278-282 | Received 20 Aug 2024, Published online: 25 Nov 2024
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Abstract
Discovery of Benzodiazepine receptors in spinal cord in 1986 by Faull and Villiger, triggered the use of intrathecal Midazolam for analgesia. Midazolam is known to produce anti nociception and potentiate the effect of local anesthetics when given in neuraxial blockade. Many workers have studied the effect of Midazolam to Bupivacaine with variable results on the duration and quality of spinal block. A prospective randomised study was conducted to compare the clinical effects of intrathecal Midazolam and Clonidine as Adjuvants to spinal Bupivacaine in patients undergoing infra‐umbilical surgeries under spinal anaesthesia in Department of Anaesthesiology after approval from the Ethics Committee and patient consent. Mean time of total duration of analgesia was 305±43 minutes in group BC and was 416.3±22.6 minutes in group BM, the p value was <0.01 and was significant. There was significant difference at 4 and 6 hours p<0.01. No significant difference was found between the groups during 2, 8, 12, 24 hours of VAS p>0.05.
How to cite this article:
R. Thanuja, T.K. Haridadeeswaran, P.S. Kalesh and C. Lakshmi. Efficacy of Clonidine (30μg) and Midazolam (2mg) as Intrathecal Adjuvants to Bupivacaine on Block Characteristics and Post‐Operative Analgesia.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.278.282
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.278.282