Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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The Role of Histopathology with Special Emphasis on Frozen Section Biopsy in Detection of COVID Associated Mucormycosis
Vijaya Lakshmi Seetha, Tholem Sripriya, Sanjay Kishve and GVRN Krishna Kanth
Page: 227-231 | Received 20 Aug 2024, Published online: 23 Nov 2024
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Abstract
Mucor mycosis is a well described fulminant fungal infection that presents acutely. COVID‐19 associated mucor mycosis (CAM) is a life threatening infection which is on rise during second wave especially in immuno compromised individuals like uncontrolled Diabetes Mellitus, Hematological malignancies etc. Early diagnosis on frozen section biopsies decreases turn around time compared to permanent sections and helps in early initiation of therapy thus decreasing the mortality and morbidity due to rapid extension of Mucor mycosis within no time of infection. Objective is to study the role of histopathology in mucor mycosis and to evaluate the statistical diagnostic accuracy of frozen section in post COVID‐19 patients. Present study was carried out in Histopathology section, Department of pathology, ESIC, Sanathnagar, Hyderabad. It’s an retrospective cross sectional study with sample size of 60 tissue biopsies including frozen sections from ENT Department over a period of 1 year from January 2021 to December 2021. Among 20 frozen sections, 12 were diagnosed as mucor mycosis that were confirmed on permanent HandE sections and special stains like GMS, PAS. 08 frozen sections were negative for mucor, out of which 01 came positive on permanent HandE sections. COVID‐19 associated mucor mycosis were seen in 26 cases(76%) among 35 total mucor positive cases. 100% positivity is seen among diabetic patients. Although permanent sections still remain the gold standard, Frozen section biopsies is a specific and sensitive method to make a quick initial diagnosis of mucor mycosis that allows immediate surgical intervention and early initiation of antifungal therapy with Amphotericin B.
How to cite this article:
Vijaya Lakshmi Seetha, Tholem Sripriya, Sanjay Kishve and GVRN Krishna Kanth. The Role of Histopathology with Special Emphasis on Frozen Section Biopsy in Detection of COVID Associated Mucormycosis.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.227.231
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.227.231