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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Effect of Long‐Term Inhaled Corticosteroids Therapy on Cognitive Function in Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease

Sulakshana Gautam, Ankit Kumar and Mukul Saxena
Page: 19-22 | Received 20 Aug 2024, Published online: 14 Nov 2024

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https://doi.org/10.36478/makrjms.2024.12.19.22

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Abstract

Inhaled corticosteroids (ICS) are widely used for managing bronchial asthma and chronic obstructive pulmonary disease (COPD). However, elevated corticosteroid levels have been associated with cognitive impairment. This study investigates the impact of long‐term inhaled corticosteroid therapy on cognitive function in patients with bronchial asthma and COPD. A prospective study was conducted at Mahamaya Rajkiya Allpathic Medical College, Ambedkarnagar, from December 2021 to May 2022. A total of 139 inpatients with COPD and bronchial asthma were enrolled. Patients were divided into three groups based on their ICS treatment duration: 43 newly diagnosed patients (group 1), 34 patients on ICS for 0.5‐1 year (group 2) and 62 patients on long‐term ICS therapy (>2 years, group 3). Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale, with scores of 24 or above considered normal. Cognitive impairment was observed in 56 patients (90.3%) from group 3 (long‐term ICS), 25 patients (73.5%) from group 2 (intermediate therapy) and 27 patients (62.7%) in group 1 (newly diagnosed). A significant association was found between the duration of ICS therapy and cognitive decline, with higher impairment rates observed among those on long‐term treatment. The findings indicate a significant association between the duration of ICS therapy and cognitive decline in patients with bronchial asthma and COPD. Long‐term ICS use may contribute to cognitive impairment, highlighting the need for regular cognitive assessments in these patients.

How to cite this article:

Sulakshana Gautam, Ankit Kumar and Mukul Saxena. Effect of Long‐Term Inhaled Corticosteroids Therapy on Cognitive Function in Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.19.22
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.19.22