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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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A Prospective Study of Adverse Drug Reactions to Antipsychotic Agents and its Causality Assessment in Psychiatry Ward of a Tertiary Care Hospital

Anish Bhanu, Priyanka Singh, Jiyo Chacko, Santosh Pillai and Liya Roslin Joseph
Page: 101-107 | Received 20 Aug 2024, Published online: 16 Nov 2024

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https://doi.org/10.36478/makrjms.2024.12.101.107

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Abstract

Adverse Drug Reactions (ADRs) is one of the most common reasons for discontinuation of antipsychotic treatment. The aim of the present study is to identify the pattern of ADRs in psychiatric in‐patients on antipsychotic drugs and to assess the causality, severity, predictability and preventability of adverse events. The present study was a descriptive cross‐sectional study conducted among the inpatients in the Psychiatry ward for a study period of one and half year. The sample size included all the ADRs due to anti psychotics medications which were reported by patients and confirmed by the physician. A total of 220 ADRs were collected from 83 inpatients. The incidence of ADR was slightly more in females (51.80%) and the majority of them were diagnosed with schizophrenia subtype (56.36%). The maximum number of ADRs reported was by patients being treated with an atypical agent clozapine (35%) followed by a typical agent chlorpromazine (19.54%). Using WHO‐UMC criteria, the majority of ADRs (72.27%) in our study belonged to the category of possible. Specific treatments were required for management of ADRs consisting of extra‐pyramidal syndromes (EPS). According to WHO ART system organ class, central and peripheral nervous system were the most affected classes. The study supports the importance of baseline investigations and active surveillance for early detection and prevention of ADRs. Also poly pharmacy should be avoided as far as possible and percentage method should be used in case where higher dose of antipsychotic is required.

How to cite this article:

Anish Bhanu, Priyanka Singh, Jiyo Chacko, Santosh Pillai and Liya Roslin Joseph. A Prospective Study of Adverse Drug Reactions to Antipsychotic Agents and its Causality Assessment in Psychiatry Ward of a Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.101.107
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.101.107