Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Vitamin D insufficiency is a widespread global health issue, significantly impacting skeletal and neuromuscular health. Despite its prevalence, vitamin D deficiency often goes unrecognized due to its subtle symptoms. While oral vitamin D supplementation is a common treatment, patient adherence is often poor, leading to the exploration of alternative treatment modalities, such as high‐dose intermittent vitamin D therapy. This prospective, randomized, open‐label study was conducted on 80 adults with severe vitamin D deficiency, defined by serum 25(OH)D levels below 30 ng/mL. Participants were randomly assigned to two groups: one received oral cholecalciferol (60,000 IU every other day for 20 days) and the other received a single intramuscular (IM) injection of cholecalciferol (600,000 IU). Serum levels of 25(OH)D, PTH, calcium, phosphorus and alkaline phosphatase (ALP) were measured at baseline, 6 weeks and 12 weeks to assess the efficacy of the treatments. Both treatment groups showed significant improvements in serum 25(OH) D levels. The intramuscular group exhibited a more consistent and sustained increase in 25(OH)D levels compared to the oral group. PTH levels decreased significantly in both groups, with no significant differences between them. Calcium and ALP levels remained stable, with minor variations that were not clinically significant. Both oral and intramuscular cholecalciferol are effective in treating severe vitamin D deficiency. However, intramuscular administration may offer a more consistent and sustained increase in 25(OH)D levels. Further research is needed to compare the long‐term efficacy and safety of these two treatment modalities in larger, more diverse populations.
How to cite this article:
Shashank Prakash, Hima Chauhan, Rajnand Kumar, Nitish Kumar and Ajay Bharti. Comparative Efficacy of Oral vs. Intramuscular Cholecalciferol in Treating Severe Vitamin D Deficiency.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.91.97
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.91.97