Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Epilepsy complicates approximately 0.6 per 100 of all pregnancies. Epilepsy in pregnancy has a bearing on pregnancy course and neonatal outcomes. Indian studies in this regard are sparse, old and moreover were undertaken mostly by obstetricians. The present study was planned looking from a pediatrician’s perspective in order to study all possible neonatal outcomes born to mothers with epilepsy delivered by any mode. The data consisted of retrospective (old patient records with obstetric and neurological details including EEG and MRI reports) and prospective data (monitored from the rst antenatal visit to the delivery regularly by obstetricians and neurologists) conducted in a tertiary care government medical college hospital. Pregnant women with Epilepsy on Anti Epileptic Drugs AED and their newborns born by caesarean section were enrolled from 2017‐ 2020. These women were treated according to their epilepsy type, focal and generalized and was followed for certain events (outcome) from delivery till discharge. These outcomes were compared between the test groups (mothers with >1 AED, not well controlled epilepsy and associated comorbidities ) and the control groups (mothers with 1 AED, well controlled epilepsy and no associated comorbidities). Statistical Analysis SPSS vs 17 software used for statistical analysis. Descriptive analysis, Chi Square test and multiple logistic regression were used. Statistical level of significance was xed at p<0.05. 55 pregnant women with epilepsy and their 55 newborns were seen. Neonatal outcome was adverse in 58% babies., 47% were born to mothers with comorbidities. 25 newborns (45%) had low birth weight, 15 (27%) were preterm, 20 (36%) had jaundice. 18 (33%) were small for gestational age, 8 babies (15%) had congenital anomalies (cardiac‐7., non cardiac‐3). There were 2 neonatal deaths (4%). Statistically signi cant outcome was found with respect to prematurity in those with >1 AED group and also was significant with respect to prematurity, Low Birth Weight LBW, Intrauterine Growth Retardation IUGR in those with co morbidities. The outcome of newborns is in uenced by the controlledness of epilepsy in mothers, number of AED used and those mothers with comorbidities.
How to cite this article:
R.Y. Kalpana, S. Praveenkumar and G. Vijayalakshmi. Profile and Outcome of Newborns Born to Mothers with Epilepsy: A Pediatrician’s Perspective.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.77.83
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.77.83