Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Cancer of the large bowel (colorectal cancer) includes all cancer originating from the cecum to the anus. The integration of COX‐2 and HER‐2/NEU markers into clinical practice could redefine diagnostic accuracy and personalize treatment strategies, leading to improved patient management and outcomes. To correlate COX‐2 and HER‐2/NEU IHC markers with histological grades of colorectal adenocarcinoma, to study the pattern of colorectal malignancies with respect to (a) Age, Sex, and Site (b) Clinical presentation (c) Treatment modalities. A hospital‐based cross‐sectional retrospective and prospective study done on 50 cases with surgery references for symptoms of colorectal malignancies or biopsy‐proven colorectal adenocarcinoma, undergoing admission in general surgical wards, emergency wards and patients with surgery references for symptoms of colorectal malignancies or biopsy‐proven colorectal adenocarcinoma from other departments like Medicine, Gastroenterology, Radiotherapy, in JLN Medical College and Hospitals, Ajmer in the time period between January 2019 to January 2024. All investigations relevant with pre anaesthetic check up along with X‐Ray‐ Flat plate abdomen (erect) and Chest, USG whole abdomen and CT/ MRI, histopathology study of the resected specimen, IHC markers study for COX‐2 and HER‐2/ NEU was performed. Out of all the cases, the age groups 41‐60 years and 60‐80 years each had 19 (38%) cases. Histologically 9 cases of moderately differentiated adenocarcinoma and 4 cases with well differentiated adenocarcinoma showed HER‐2 / NEU positivity. 21 cases of moderately differentiated adenocarcinoma and 12 cases with well differentiated adenocarcinoma showed COX‐2 positivity. The integration of COX‐2 and HER‐2/NEU markers into clinical practice could redefine diagnostic accuracy and personalize treatment strategies, leading to improved patient management and outcomes.
How to cite this article:
Kushal Goyal, Shyam Bhutra, Divvy Rawat and Rohit Jain. A Comprehensive Study of Colorectal Adenocarcinoma and its Correlation with COX‐2 and HER‐2/NEU IHC Markers.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.505.508
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.505.508