Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Melasma is an acquired pigmentary disorder caused by increased melaocytosis and melanogenesis and found to be associated with thyroid autoimmunity. To ascertain if a relationship exists between serum levels of T3, T4, thyroid stimulating hormone (TSH) and anti‐thyroid peroxides antibodies (anti‐TPO) with melasma. This case‐control study was carried out on 50 melasma cases and 50 age matched healthy females with no history of melasma as controls, their blood was drawn and examined for thyroid function tests including T3, T4, TSH and anti TPO antibodies. There was significant difference in the mean level of T3, T4, TSH and anti TPO between patient and control group. Serum T3 levels surpassed the normal levels in 75.8% of the patients and 49.1% of the controls, mean serum TSH levels was found to be 3.16 amongst melasma patients. In 24.7% of the patients and 6.8% of the controls, serum anti‐TPO level was higher than normal. Thyroid disorders are frequent amongst melasma cases, the most common being hypothyroidism. Diagnosis and management of thyroid disease in melasma cases may improve quality of life, prevent thyroid related complications and improve outcome of melasma treatment.
How to cite this article:
Fatima Razvi and Farheen Kahkashan Ahmed. Melasma and Thyroid Autoimmunity: A Case Control Study to Evaluate Association, If Any.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.473.478
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.473.478