Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Serum Creatinine‐Albumin Ratio(CAR) as a Prognostic Marker of Sepsis and it's Edge Over Procalcitonin(PCT) in Predicting 30 Day Mortality in Patients with Sepsis: A Comparative Prospective Study From an Intensive Care Unit of a Tertiary Care Center in Kolkata
Vivek Paul Chowdhury, Subham Dey, Md Rizwan Ul Haque and Md Jawed Ali Warsi
Page: 413-418 | Received 25 Sep 2024, Published online: 31 Oct 2024
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Abstract
Sepsis is a critical condition characterized by a dysregulated host response to infection, leading to high mortality rates. Timely diagnosis and effective management are crucial for improving outcomes. While Procalcitonin (PCT) has been a common biomarker for sepsis prognosis, its efficacy in predicting mortality remains debated. This comparative prospective study evaluates the prognostic value of the Serum Creatinine‐Albumin Ratio (CAR) over PCT in predicting 30‐day mortality among septic patients in an ICU of a tertiary care center in Kolkata. Data were collected from 100 patients between January and June 2024, including demographics, clinical parameters and laboratory measurements of CAR and PCT. The results demonstrated a significant association between elevated CAR and higher mortality, with 65.1% of patients with increased CAR succumbing to sepsis compared to 35.7% with decreased CAR (p=0.036). In contrast, changes in PCT levels showed no significant correlation with outcomes (p=0.863). Logistic regression analysis confirmed CAR's superior predictive power, with an odds ratio of 3.36 for increased mortality risk. The study highlights CAR's dynamic nature, with significant increases from day 0 to day 3 (p<0.001), further underscoring its potential as a robust prognostic marker. While the study is limited by its single‐center design and small sample size, it suggests that integrating CAR into routine sepsis management could enhance mortality predictions and treatment strategies. Further research in larger, multi‐center studies is recommended to validate these findings and improve sepsis care protocols.
How to cite this article:
Vivek Paul Chowdhury, Subham Dey, Md Rizwan Ul Haque and Md Jawed Ali Warsi. Serum Creatinine‐Albumin Ratio(CAR) as a Prognostic Marker of Sepsis and it's Edge Over Procalcitonin(PCT) in Predicting 30 Day Mortality in Patients with Sepsis: A Comparative Prospective Study From an Intensive Care Unit of a Tertiary Care Center in Kolkata.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.413.418
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.413.418