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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Study to Correlate the Clinical Findings with FNAC (Positive or Negative) Reports and Post‐Operative Histopathology Reports in Patients with Breast Carcinoma

Ghanashyam A. Ingle, Sumit Rana, Anuradha Panchal and Gangadhar L. Anmod
Page: 405-409 | Received 20 Aug 2024, Published online: 30 Oct 2024

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Abstract

Fine Needle Aspiration Cytology (FNAC) is a critical diagnostic tool in the initial assessment of breast carcinoma. This study aims to assess the correlation between clinical findings, FNAC outcomes and post‐operative histopathological reports, providing insights into the diagnostic accuracy and predictive value of FNAC in breast cancer management. A retrospective analysis was conducted on 200 patients diagnosed with breast carcinoma at a single tertiary care center. The study evaluated the concordance between FNAC results and definitive histopathological findings post‐surgery. Correlations with clinical examination findings were analyzed using Pearson's correlation coefficient and the impact of various imaging modalities on FNAC predictive accuracy was assessed through sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) calculations. The concordance between FNAC results and histopathology showed variability across different types of breast carcinomas, with odds ratios ranging from 0.36 for inflammatory carcinoma to 0.59 for lobular carcinoma. Clinical findings such as palpable mass and skin retraction exhibited moderate to strong positive correlations with FNAC results (r=0.45‐0.67). Imaging enhancements, particularly MRI, significantly improved the sensitivity (98.8%) and NPV (91.2%) of FNAC, supporting its diagnostic use in complex cases. FNAC, when integrated with clinical examination and targeted imaging, provides a robust framework for the preliminary diagnosis of breast carcinoma. However, the variability in concordance rates across different tumor types and the dependence on technical expertise highlight the need for careful clinical and pathological integration in FNAC application. Future research should focus on multi‐center studies to validate these findings and explore the benefits of incorporating advanced imaging techniques to refine FNAC accuracy further.


How to cite this article:

Ghanashyam A. Ingle, Sumit Rana, Anuradha Panchal and Gangadhar L. Anmod. Study to Correlate the Clinical Findings with FNAC (Positive or Negative) Reports and Post‐Operative Histopathology Reports in Patients with Breast Carcinoma.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.405.409
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.405.409