Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Pain management during and after major surgeries such as total abdominal hysterectomy remains a significant clinical challenge as the post‐operative period is a vulnerable period that triggers various hemodynamic instability, pain, etc. These can be handled better by adopting certain pre‐operative measures like the use of preemptive analgesics like Gabapentin and reducing the need for opioids. We aimed to evaluate the efficacy, safety, quality of analgesia and side effects of Gabapentin as a pre‐emptive analgesic by comparing it with that of a placebo. It was a Comparative study of Sixty female in patients undergoing total abdominal hysterectomy of American Society of Anaesthesiologists (ASA) grade I and grade II, between the age group 35‐60 years selected by simple random sampling technique. They were divided into two groups of thirty each. Group‐G (Gabapentin)‐received Tab. Gabapentin 300mg orally, 2 hours before the surgery with sips of water. Group P‐P (placebo)‐ received none. All patients received a combined spinal epidural anaesthesia followed by epidural top ups for pain relief. The outcome was compared between the groups for the mean time of onset of sensory block, total number of epidural bolus in 24 hrs, hemodynamic changes and the VAS at 2, 4, 8, 12 and 24 hours. SPSS for Windows (version 22.0) was used for analysis. Group‐ G showed significantly lower VAS scores postoperatively compared to Group‐ P with a p value<0.0001 at every interval. Significantly reduced requirements of the number of epidural top‐ups were demonstrated in Group‐ G compared to Group‐ P postoperatively, p<0.5. Intra operatively Hemodynamic were well maintained in Group‐G when compared to Group‐P as seen with significant differences in mean arterial blood pressures between the two groups p<0.001. Pre‐emptive use of Tab. Gabapentin 300mg orally significantly reduces the number of post‐operative epidural bolus requirements and post‐operative pain in patients undergoing total abdominal hysterectomy under combined spinal epidural anaesthesia Maintaining stable intra operative Hemodynamic.
How to cite this article:
R.P. Prashanth and C.N. Malathi. Evaluating Gabapentin as a Pre‐Emptive Analgesic During Combined Spinal Epidural Anesthesia in Patients Undergoing Total Abdominal Hysterectomy.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.359.364
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.359.364