Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Evaluating liver fibrosis in chronic hepatitis B (CHB) patients is crucial for guiding management and treatment decisions. Liver biopsy, while the gold standard, is invasive and associated with complications. Magnetic Resonance Elastography (MRE) and Transient Elastography (TE), commonly known as FibroScan, have emerged as non‐invasive alternatives for liver stiffness measurement (LSM) in assessing fibrosis. This study compares the diagnostic accuracy and effectiveness of MRE and TE in staging liver fibrosis in CHB patients. In this cross‐sectional study, 30 chronic hepatitis B (CHB) patients were recruited. Each patient underwent both MRE and TE and liver stiffness values were measured using predefined cut‐offs. For TE, fibrosis stages were defined as: <7 kPa (F0), 7‐10 kPa (F1), 10‐13 kPa (F2), 13‐16 kPa (F3) and >16 kPa (F4). MRE measurements categorized fibrosis as normal (<2.5 kPa) and advanced fibrosis or cirrhosis (>5.0 kPa). Spearman correlation analysis and Kappa statistics were used to assess the correlation and agreement between MRE and TE, respectively. TE results showed that 60% of patients had no significant fibrosis (F0), 30% had mild fibrosis (F1) and 6.7% had cirrhosis (F4). MRE classified 83.3% of patients as F0, with fewer patients at advanced fibrosis stages (3.3% each in F3 and F4). Spearman’s correlation analysis revealed a strong correlation between TE and MRE scores (rho=0.692, p<0.001). However, only moderate agreement was found between TE and MRE (Kappa k=0.484, p<0.001), indicating some variability between the methods. MRE demonstrated superior accuracy in detecting early fibrosis and provided a more comprehensive liver stiffness assessment. MRE offers higher diagnostic accuracy and reliability in staging liver fibrosis compared to TE, particularly in identifying early and advanced fibrosis stages. However, both methods are valuable non‐invasive tools for clinical decision‐making in CHB patients. Given MRE’s greater precision but higher resource requirements, the choice between these two methods may depend on the clinical setting, availability and patient characteristics.
How to cite this article:
Ashok Kumar Verma, Abhilasha Pratihar, Manish Gautam and Vinay Kumar. Comparing Fibroscan with MR Elastography in Staging of Fibrosis as Noninvasive Methods in Chronic Hepatitis B Patients.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.306.313
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.306.313