Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Clinical Study of Helicobacter Pylori Infection in Operated Patients of Perforated Duodenal Ulcer During Post‐Operative Period of 6 Weeks with Endoscopic Cup Mucosal Biopsy and Rapid Urease Test
Jaiwant Mahurkar and S.M. Veerendraswamy
Page: 272-279 | Received 20 Aug 2024, Published online: 24 Oct 2024
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Abstract
Perforation is one of the complications of duodenal ulcer. Its causative factors include Helicobacter pylori, NSAIDs and others. The treatment for perforated duodenal ulcer is simple closure of the perforation with an mental patch (Graham’s/Modified Graham’s patch repair). Yet even after surgery, few patients can have persistence of Helicobacter pylori in their post‐op follow up period. This clinical study was done to investigate the prevalence and etiological role of Helicobacter pylori infection in patients who have undergone surgery for perforated duodenal ulcers. Objectives were to determine the prevalence of Helicobacter pylori infection in post‐operative patients with perforated duodenal ulcer after duration of at least 6 weeks and to assess the role of Helicobacter pylori in the etiology of duodenal ulcers. A prospective study comprising of 30 patients, (who met inclusion criteria) from the period of July 2022 to December 2023, was done, who have undergone surgery for perforated duodenal ulcer and got discharged and later came for post‐op follow up in surgery OPD, 6 weeks post surgery. All 30 patients were advised Upper Gastro‐intestinal endoscopy followed by Rapid Urease test. The results were observed, analysed and compared with similar other studies. Our study involved 30 patients both males and females, age between 18‐75 years, who have undergone surgery for perforated duodenal ulcer and got discharged and later came for post‐op follow up in surgery OPD , 6 weeks after surgery. Upper gastro‐intestinal endoscopy was done for them. Out of those 30 patients, 18 patients’ rapid urease test was positive (60%) and 12 patients’ rapid urease test was negative (40%). This showed significant prevalence of H.pylori in post‐op follow up patients of perforated duodenal ulcer. Association of H.pylori in patients of post‐op follow up cases with perforated duodenal ulcer is significant (60%). Alcohol, smoking and NSAIDs were significant risk factors, associated with perforated duodenal ulcer. Patients presenting with a perforated peptic ulcer should simple closure of the perforation. Additionally, they should receive treatment to promote healing of the ulcer and eliminate the H. pylori infection. The eradication of this organism is important as it reduces the likelihood of ulcer recurrence and perforation following the closure of the ulcer.
How to cite this article:
Jaiwant Mahurkar and S.M. Veerendraswamy. Clinical Study of Helicobacter Pylori Infection in Operated Patients of Perforated Duodenal Ulcer During Post‐Operative Period of 6 Weeks with Endoscopic Cup Mucosal Biopsy and Rapid Urease Test.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.272.279
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.272.279