Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Thyroid hormones influence renal development, renal glomerular filtration rate (GFR), electrolytes and water homeostasis. The location of the present study is situated at regions with high prevalence of thyroid dysfunctions. The objective of this Longitudinal case‐control study is to substantiate the effects of thyroid hormonal status on kidney by estimating serum creatinine, serum urea, albumin‐to‐creatinine ratio (ACR) and estimated GFR (eGFR) among drug naïve thyroid patients under treatment for more than 2 months and age‐and sex‐matched control group. The study includes 48 patients with thyroid dysfunction in a drug naïve status, 40 thyroid dysfunction patients under treatment and 44 healthy control in the age group of 25‐55 years. The collected blood and urine samples from the study population have been estimated for the study parameters. Both Chronic Kidney Disease Epidemiology (CKD‐ EPI) equation and four‐variable Modification of Diet in Renal Disease (MDRD) Study equation were used to calculate eGFR. The mean values of serum creatinine, urea and ACR are significantly increased among untreated patients with primary hypothyroidism, with the decrease in the eGFR, in comparison to healthy control group (p<0.001)., whereas patients on treatment for hypothyroidism show fall in serum creatinine, serum urea and ACR level, with increase in eGFR values compared with drug naïve primary hypothyroid patients (p<0.001). In addition, the results of eGFR and ACR are signifi‐ cantly correlated with thyroid‐stimulating hormone (TSH) values. Statistically significant alteration in renal function parameters is associated with untreated primary hypothyroidism. Moreover, with the initiation of the treatment for the same can cause reversal of the altered status of renal function.
How to cite this article:
Gurrala Srinivasa Reddy, Aravelli Laxmi and Priyanka Vaitla. A Study of Thyroid and Renal Tests in Patients with Hyper, Hypo and Euthyroid Diseases.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.230.234
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.230.234