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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Efficacy of Two Different Doses of Vitamin D Supplementation in Pregnant Women and Their Impact on Neonatal Vitamin D Levels

Naimisha Reddy Kasireddy, G. Bharath Kumar and Gogineni Divya Chowdary
Page: 205-209 | Received 05 Jul 2024, Published online: 03 Sep 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.11.205.209

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Abstract

Vitamin D deficiency during pregnancy is a pervasive issue that has significant implications for both maternal and neonatal health. Adequate supplementation strategies are crucial for improving outcomes, but the optimal dosage remains under debate. This study evaluates the efficacy of two different doses of vitamin D supplementation in pregnant women and their impact on neonatal vitamin D levels. A total of 220 pregnant women were enrolled in a randomized controlled trial to receive either 2000 IU or 4000 IU of vitamin D daily starting from their second trimester until delivery. Maternal blood samples were collected at the time of enrollment and at delivery to measure serum vitamin D levels. Neonatal serum vitamin D levels were measured within 24 hours after birth. Of the participants, 46.4% achieved adequate maternal vitamin D levels (>30 ng/ml) at delivery in the higher dose group compared to 24.5% in the lower dose group achieving adequate neonatal vitamin D levels. The odds ratio for achieving adequate neonatal vitamin D levels in the higher dose group was 2.50 (95% CI: 1.85‐3.38., P=0.0001), indicating a significant effectiveness of higher dosages. Furthermore, a high correlation (OR=2.10, 95% CI: 1.60‐2.75; P=0.0002) was found between maternal and neonatal vitamin D levels, supporting the vertical transfer of vitamin D. Higher doses of vitamin D supplementation during pregnancy are more effective in achieving adequate vitamin D levels in both mothers and neonates. These findings support the need for revising current vitamin D supplementation guidelines for pregnant women to ensure optimal neonatal health outcomes.

How to cite this article:

Naimisha Reddy Kasireddy, G. Bharath Kumar and Gogineni Divya Chowdary. Efficacy of Two Different Doses of Vitamin D Supplementation in Pregnant Women and Their Impact on Neonatal Vitamin D Levels.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.205.209
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.205.209