Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
In India, stroke incidence is rising due to modifiable risk factors, making it a leading cause of premature death and disability. Fibrinogen is a crucial inflammatory marker involved in the pathophysiology of various cardiovascular events, including stroke. Its levels tend to increase following an acute stroke, serving as an independent risk factor for recurrence and predicting adverse cardiovascular outcomes. To evaluate the relationship between serum fibrinogen levels and stroke severity. This prospective, observational study involved 100 patients with clinically diagnosed stroke admitted to a tertiary care hospital, Gujarat. Exclusion criteria included malignancy, trauma, transient ischemic attacks (TIA) and chronic hepatic or renal diseases. Data collection involved demographic information, clinical examination and relevant investigations, including serum fibrinogen levels. For all patients, the National Institutes of Health Stroke Scale (NIHSS), Intra cerebral Hemorrhage (ICH) score and Modified Rankin Scale (MRS) were calculated. The mean age of participants was 62.23±12.16 years, with a predominance of males (70%) and ischemic strokes (75%). Common risk factors included hypertension (56%) and diabetes (43%). The mean plasma fibrinogen level among stroke patients was 531.1±200.65 mg/dL. Patients with hypertension, diabetes, obesity and smoking habits had significantly elevated fibrinogen levels compared to their counterparts. Elevated fibrinogen levels correlated strongly with increased stroke severity [NIHSS: r=0.75, p<0.001; MRS: r=0.82, p<0.001]. The findings highlight the significant association between elevated fibrinogen levels and stroke severity, particularly in older patients and those with comorbid conditions. This strong correlation supports the potential role of fibrinogen as a valuable biomarker for assessing clinical outcomes in stroke patients, emphasizing the need for routine monitoring in clinical practice.
How to cite this article:
Vishal Miyatra, Brinda Mevada, Amrutbhai P. Zala, Palak S. Patel and Anjali Oza. The Role of Serum Fibrinogen as a Prognostic Biomarker in Patients of Acute Cerebrovascular Accident.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.11.124.129
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.11.124.129