Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
To study of adverse drug reactions and treatment outcome in patients under shorter coarse MDR treatment. Study was conducted on 66 patients who were sputum CBNNAT positive and RIF resistant, till all the subject’s treatment was completed and all the adverse drug reactions of the patient during the treatment coarse and what is the final outcome. The mean age of all 66 patients is 41±14 with most common age group of patients were in between 20‐39 years. Males are more in number. Agriculture workers (42%) and daily wage labourers (39%) are most common occupational group in this study. The most common comorbid condition of the subjects in this study is Diabetes mellitus. Majority were from rural areas. Most of the patients had bmi of <18.5. Almost 26% of the patients were anaemic. The most common Chest X‐ray finding among study participants is cavitatory disease (39%), B/L diffuse infiltrates (39%). Mostly lesions were located on the right side. Adverse drug reactions observed in the patients were mostly in 20‐39 age group and mostly in males occurring in first three months of initiation of treatment. Adverse drug reactions were mostly observed in subjects with comorbidities, and with addictions. Gi related adverse reactions were common and were easily managed by supportive management like adding proton pump inhibitors. On grading the adverse drug reactions by using Modified Hartwig and Siegel Scale. Majority of the adverse drug reactions were graded in moderate level 4a. As per Naranjo causality assessment Scale majority of the adverse drug reactions were probable ADR’S. Out of 66 patients 67% had favourable outcome and 32% had unfavourable outcome.
How to cite this article:
P.N. Kiran Kumar, C. Ramanjula Reddy and P. Suresh. Study of Adverse Drug Reactions and Treatment Outcome in Patients Undergoing Multi Drug Resistance Tuberculosis.
DOI: https://doi.org/10.36478/10.36478/makrjms.2022.4.103.107
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2022.4.103.107