Research Journal of Biological Sciences
ISSN: Online 1993-6087ISSN: Print 1815-8846
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Correlation of Cyclooxygenase 2 (Cox-2) Presentation and Inflammatory Cells Infiltration in Colorectal Cancer: A Histopathological and Immunohistochemical Study
F. Naghshvar , Z. Torabizadeh , O. Emadian , A. Khalilian , I. Maleki and K. Enami
Page: 916-918 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
Colorectal cancer is the third most common cancer in the world and the second most common cause of cancer related death. Cox-2 has been reported to be significantly increased in up to 85% of human sporadic colorectal carcinoma. Little is known about interaction between Cox-2 and inflammatory cells of colorectal carcinoma. In all cases, archival H and E slides of the primary tumor were retrieved and reviewed to confirm pathological facture and to select suitable tissue blocks for Immunohistochemical analysis. The expression of Cox-2 was positive (grade 3-7) in 71.3% of tumors and associated with neutrophils, eosinophil, mast cell, macrophages and CD3+ lymphocytes (p = 0.001). Correlation of Cox-2 expression and CD8 lymphocytes was not significant (p = 0.569). The main purpose of this study was to evaluate the interaction between the Cox-2 expression and inflammatory cells. We showed that there is a close relationship of Cox-2 expression and mast cells, neutrophils, eosinophils, macrophages, lymphocyte (CD3+). The only exception was CD8 positive lymphocytes.
How to cite this article:
F. Naghshvar , Z. Torabizadeh , O. Emadian , A. Khalilian , I. Maleki and K. Enami . Correlation of Cyclooxygenase 2 (Cox-2) Presentation and Inflammatory Cells Infiltration in Colorectal Cancer: A Histopathological and Immunohistochemical Study.
DOI: https://doi.org/10.36478/rjbsci.2008.916.918
URL: https://www.makhillpublications.co/view-article/1815-8846/rjbsci.2008.916.918