Research Journal of Biological Sciences
ISSN: Online 1993-6087ISSN: Print 1815-8846
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Plasminogen Activator Inhibitor-1-675 4G/5G and Methylenetetrahydrofolate Reductase Gene Variants in Young Acute Myocardial Infarction and Juvenile Ischemic Stroke
Giulia Bivona , Chiara Bellia , Salvatore Cammarieri , Bruna Lo Sasso , Rosachiara Carollo , Rosalinda Raineri , Gaia Chiarello , Antonietta Caruso and Marcello Ciaccio
Page: 1341-1343 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
Cardiovascular diseases often recognize a hereditary-familial genetic risk patterns and a substantial proportion of variability in clinical features of atherosclerosis could probably be explained by genetic factors. Aim of this study is to compare prevalence of factor V Leiden, factor II 20210A, PAI-1-675 4G/5G and MTHFR C677T gene variants in 2 cardiovascular disease clinical features: young acute myocardial infarction (<50 years) and ischemic stroke. Plasminogen Activator Inhibitor-1-675 4G/5G didn’t show significant difference between patients and controls while, between patient groups, the polymorphism was most present in myocardial infarction group than in juvenile stroke. Polymorphisms in Homocysteine metabolism: MTHFR C677T variants was significantly higher in patients with myocardial infarction compared with those affected by ischemic Stroke.
How to cite this article:
Giulia Bivona , Chiara Bellia , Salvatore Cammarieri , Bruna Lo Sasso , Rosachiara Carollo , Rosalinda Raineri , Gaia Chiarello , Antonietta Caruso and Marcello Ciaccio . Plasminogen Activator Inhibitor-1-675 4G/5G and Methylenetetrahydrofolate Reductase Gene Variants in Young Acute Myocardial Infarction and Juvenile Ischemic Stroke.
DOI: https://doi.org/10.36478/rjbsci.2008.1341.1343
URL: https://www.makhillpublications.co/view-article/1815-8846/rjbsci.2008.1341.1343