Research Journal of Biological Sciences
ISSN: Online 1993-6087ISSN: Print 1815-8846
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Hyperhomocysteinemia in Patients with Cognitive Impairment
Marcello Ciaccio , Giulia Bivona , Antonino Tuttolomondo , Chiara Bellia , Riccardo Di Sciacca , Gaia Chiarello , Bruna Lo Sasso , Rosa C. Carollo , Domenico Di Raimondo , Antonio Pinto and Giuseppe Licata
Page: 1337-1340 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerative diseases. Not all of patients with Mild Cognitive Impairment (MCI) finally develop dementia and it is interesting to investigate the role of possible markers for early diagnosis. Hyperhomocysteinemia is associated to several pathologies including cognitive impairment; aim of this study is to evaluate the correlation between cognitive performance assessment and homocysteine plasma levels. Total 74 patients and 75 healthy controls were enrolled and MCI were defined by a MMSE score lower than 26 after adjustment for years of schooling. Homocysteine plasma levels were determined. Homocysteine levels significantly raised in patients with cognitive impairment and showed a significant negative association with MMSE score. Finally, our data show that a moderate risk of cognitive impairment could be associated to high homocysteine plasma levels.
How to cite this article:
Marcello Ciaccio , Giulia Bivona , Antonino Tuttolomondo , Chiara Bellia , Riccardo Di Sciacca , Gaia Chiarello , Bruna Lo Sasso , Rosa C. Carollo , Domenico Di Raimondo , Antonio Pinto and Giuseppe Licata . Hyperhomocysteinemia in Patients with Cognitive Impairment.
DOI: https://doi.org/10.36478/rjbsci.2008.1337.1340
URL: https://www.makhillpublications.co/view-article/1815-8846/rjbsci.2008.1337.1340