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Research Journal of Biological Sciences

ISSN: Online 1993-6087
ISSN: Print 1815-8846
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Serological Evaluation of Major Beta Thalassemia Patients below15 for Cytomegalovirus Infection in Iran

H. Choobineh , S.H. Alizadeh , M.K. Sharifi Yazdi , F. Vaezzadeh , H. Dargahi and A.A. Pourfatholah
Page: 584-589 | Received 21 Sep 2022, Published online: 21 Sep 2022

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https://doi.org/10.36478/rjbsci.2007.584.589

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Abstract

Thalassemia is one of the most prevalent human genetic diseases. Thalassemia genes are prevalent all over the world especially in countries on Thalassemia belt which Iran is among them. With due attention to the prevalence of this genetic disease in Iran and patients’ vital needs for regularly blood transfusion, it is necessary to study Transfusion-transmitted cytomegalovirus infection in this patients. Current study has been carried out on 309 Thalassemia patients below 15 who were receiving blood from therapeutic centers repeatedly. ELISA method was used to determine CMV-IgM seroposivity for cytomegalovirus, Also 225 healthy people below 15 were selected as control group and finally all data were analyzed by SPSS statistical software. The results of this study showed that 12.9 % of under study Thalassemia patients were seropositive for CMV-IgM antibody and 95.1% were negative. Regional separation of patients showed that the patients resided in Tehran are more infected to this virus than patients of other towns. According to this study prevalence of CMV-IgM antibody significantly higher than normal population, therefore immunity care of these patients and use CMV seronegative blood units and also hematic parents (parents with the same blood and CMV seronegative) are important.

How to cite this article:

H. Choobineh , S.H. Alizadeh , M.K. Sharifi Yazdi , F. Vaezzadeh , H. Dargahi and A.A. Pourfatholah . Serological Evaluation of Major Beta Thalassemia Patients below15 for Cytomegalovirus Infection in Iran.
DOI: https://doi.org/10.36478/rjbsci.2007.584.589
URL: https://www.makhillpublications.co/view-article/1815-8846/rjbsci.2007.584.589