Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
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Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both in vitro and in vivo
Jianzhen Lv, Zijie Wang, Li Zhang, Hai-Lian Wang, Yuande Liu, Chunyang Li, Jiagang Deng, Yi-Wang and Jin-Ku Bao
Page: 352-359 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
Mangiferin, a C-glucosylxanthone (1, 3, 6, 7-tetrahydroxyxanthone-C2-β-D-glucoside) purified from plant sources was shown to have in vitro growth-inhibitory and apoptosis-inducing activity against MCF-7 cells and it also possessed anti-tumor property on MCF-7 xenograft mice in vivo. Mangiferin triggered G2/M phase cell-cycle arrest via down-regulating cdc2-cyclinB1 singling pathway and induced apoptotic cell death through inhibiting PKC-NFκB pathway in human breast carcinoma MCF-7 cells. In addition, mangiferin had anti-cancer effects in vivo and it could decrease the volume and weight of subcutaneous tumor mass obviously as well as expanded lifespan of xenograft mice. With the molecular mechanisms of mangiferin-induced anti-tumor activities were gradually clarified, traditional Chinese medicine would become potential anti-neoplastic drugs in future cancer therapeutics.
How to cite this article:
Jianzhen Lv, Zijie Wang, Li Zhang, Hai-Lian Wang, Yuande Liu, Chunyang Li, Jiagang Deng, Yi-Wang and Jin-Ku Bao. Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both in vitro and in vivo.
DOI: https://doi.org/10.36478/javaa.2013.352.359
URL: https://www.makhillpublications.co/view-article/1680-5593/javaa.2013.352.359