Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
Abstract
GGPPS is a member of prenyl transferase family catalyzing the synthesis of GGPP (Geranylgeranyl diphosphate) from Farnesyl diphosphate (FPP) and Isopentenyl diphosphate (IPP). Using cre/loxp system, researchers got oocyte specific knockout ggpps mice. Mutation of ggpps resulted in abnormality of follicular development, granulosa cell premature luteinization, theca cell hypertrophy and multi-oocyte follicles. Interaction of oocyte and granulosa cell was also changed. Oocyte-specific knockout of ggpps mice was acquired. Follicles grew abnormally in ggpps mutation mice. Interaction of oocyte and granulosa cell was also changed.
How to cite this article:
ChunLei Song, XiuXing Wang, Xuguang Wang, Xueshan Ma, Jun Zhang, BeiBei Gao and Honglin Liu. Abnormal Follicle Development in GGPPS Conditional Knockout Mice.
DOI: https://doi.org/10.36478/javaa.2013.323.329
URL: https://www.makhillpublications.co/view-article/1680-5593/javaa.2013.323.329