Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
Abstract
This study was performed to identify whether acetamiprid could residue in liver and kidney and its effect on liver function. Fifty adult Kunming male mice weighting 25-30 g were randomly grouped and ten mice in each group (five groups: control, blank, acetamiprid alone, acetamiprid+vitamin E, vitamin E alone); all groups were administered for 35 days by intragastric gavage. The residue in the tissues had been detected by the Liquid Chromatography coupled with tandem Mass Spectrometry (LC-MS/MS) and the serum biochemistry parameters were analyzed by an automatic chemistry analyzer. Acetamiprid induced a wide range of nervous signs in mice; the concentration of acetamiprid in liver was higher than that of kidney p<0.05. Furthermore, acetamiprid increased the activity of Alanine Transaminase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP) (p<0.05 for all) but reduced the activity of Total Protein (TP) and Albumin (ALB) (p<0.05, for both). However, Vitamin E ameliorated the effects of acetamiprid on these parameters, compared to the acetamiprid only group (p<0.05). The results indicated that the liver was the main organ of acetamiprid residues and acetamiprid could affect liver function but VE could reduce acetamiprid-induced impairment.
How to cite this article:
Yi- Wang, Jiao-Jiao Zhang, Hai-Yang Xiang, Jia- Hua, Zhang and Xian-Zhong Wang. Acetamiprid Residues in Male Mice and its Effect on Liver Function.
DOI: https://doi.org/10.36478/javaa.2012.2706.2710
URL: https://www.makhillpublications.co/view-article/1680-5593/javaa.2012.2706.2710