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Journal of Animal and Veterinary Advances

ISSN: Online 1993-601X
ISSN: Print 1680-5593
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Cross-Protection of Different Vaccines Against Three Divergent Wild Animal Mexican Molecular Variants of Rabies Virus

Elizabeth Loza-Rubio , Jose Ernesto Weimersheimer Rubi and Alvaro Aguilar-Setien
Page: 140-144 | Received 21 Sep 2022, Published online: 21 Sep 2022

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https://doi.org/10.36478/javaa.2008.140.144

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Abstract

Now that canine rabies in Mexico has been controlled, most of human and animal cases are due to variants from wildlife: vampire bats, skunks and others. Although, most variants are similar in their genome, a skunk variant from Baja California Sur differs up to 19% in its genome from other rabies isolates. We wanted to test the efficiency of various commercial veterinary and human vaccines in protecting this and other wildlife viruses; the inactivated PV strain vaccine used in dog vaccination campaigns in Mexico; the recombinant vaccinia-rabies VRG vaccine, usually used by oral route was administered by parenteral route; the human vaccine produced in diploid cells (PM 3-1503 strain) and the human-used vaccine produced in VERO cells (PM strain). Three different isolates were used as challenges viruses: vampire bat, lynx/fox and hypervariable skunk virus. The protection proffered was tested by the NIH test. All 4 vaccines tested protected above the WHO’s requirements: VRG administered intramuscularly conferred the highest protection (> 5 IU). All vaccines evaluated were efficient against the skunk isolate (>5, 4, 4 and 7 IU, respectively). PV strain vaccine conferred the least protection. All vaccines tested were efficient against the hypervariable skunk isolate and also the other wildlife strain tested.

How to cite this article:

Elizabeth Loza-Rubio , Jose Ernesto Weimersheimer Rubi and Alvaro Aguilar-Setien . Cross-Protection of Different Vaccines Against Three Divergent Wild Animal Mexican Molecular Variants of Rabies Virus.
DOI: https://doi.org/10.36478/javaa.2008.140.144
URL: https://www.makhillpublications.co/view-article/1680-5593/javaa.2008.140.144