Journal of Animal and Veterinary Advances

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Systemic Effects of Sildenafil Citrate on Pregnancy and Perinatal Periods

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Medicine & Public Health Life Sciences Engineering Mathematics Biomedicine Physics Chemistry Computer Science Earth Sciences Social Sciences Business and Management Psychology Materials Science Economics Education Environment Philosophy Statistics Law Political Science and International Relations Pharmacy Dentistry Energy Linguistics Geography Finance Criminology and Criminal Justice Medicine Cultural and Media Studies History Architecture / Design Literature Biomedical Sciences Religious Studies Education & Language Food Science & Nutrition Public Health

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Abstract

Sildenafil citrate is an orally administered effective treatment for erectile dysfunction; nevertheless administrated in high concentrations produces relaxation of myometrium in pregnant women, thus sildenafil or related molecules may have future potential tocolytic application. In the present review sildenafil mechanism of action, pharmakocinetics and therapeutic use are discussed. Sildenafil is also considered a potent pulmonary vasodilator in pharmacology representing an alternative to neonates during the last month of in utero development. We conclude that studies in animals including metabolic and physiological traits in the fetus and neonates from treated dams with sildenafil in their last third of pregnancy may help to characterize neonate tolerance to asphyxia with posterior application in human perinatology.

How to cite this article:

P. Sanchez-Aparicio , D. Mota-rojas , R. Ramirez Necoechea , A. Olmos-Hernandez , M. Alonso-Spilsbury , D. Villanueva-Garcia , M.E. Trujillo-Ortega and R. Hernandez-Gonzalez . Systemic Effects of Sildenafil Citrate on Pregnancy and Perinatal Periods.
DOI: https://doi.org/10.36478/javaa.2007.267.271
URL: https://www.makhillpublications.co/view-article/1680-5593/javaa.2007.267.271