Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
Abstract
The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl4). The percentage of chiral inversion in animals with THD was 90.5±21.1 (mean±sd) and the difference with healthy animals was not statistically significant.
How to cite this article:
Castro, E. , A. Soraci , O. Tapia , F. Fogel , R. Franci , L. Denzoin and I. Ortega . Chiral Inversion of R-(-)-Fenoprofen Enantiomer in Cats with Toxic Hepatic Disease.
DOI: https://doi.org/10.36478/javaa.2006.176.183
URL: https://www.makhillpublications.co/view-article/1680-5593/javaa.2006.176.183