Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
Abstract
First identified in the cortical region, Cortistatin (CST) is an endogenous neuropeptide discovered in recent years and its effectiveness continues to be investigated in various conditions including inflammatory, endocrinological and neurophysiological conditions. The present study was conducted to evaluate the relationship between CST and some hematological parameters in acute inflammation induced by turpentine oil in rabbits. In the study, 28 New Zealand male rabbits were used and the animals were divided into control (C), turpentine (T), cortistatin (CST) and turpentine + cortistatin (CST+T) groups. Some hematological parameters such as red blood cells (RBC), White blood cells (WBC), packet cell volume (PCV, Ht), and hemoglobin were examined in the blood samples taken at the 2nd and 6th hours. In addition, Wintrobe red blood cell indices were calculated for each group and sampling time. When the findings are evaluated taking into account the difference between sampling times, no significant difference was observed between the data of groups C and CST in terms of all other parameters examined. Among the parameters examined, only WBC and Hemoglobin levels were found to have statistically significant differences (P<0.05) both between groups and between sampling times in the 6-hour data. According to the data obtained as a result of the study, it was determined that although cortistatin application played a suppressive role in inflammation in the acute period, this effect was less significant than the effect observed in conditions such as endotoxemia and sepsis.
How to cite this article:
Banu Atalay. Evaluation of Relationship Between Cortistatin Administration and Some Hematological Parameters in Acute Inflammation.
DOI: https://doi.org/10.36478/10.36478/makjava.2024.2.1.5
URL: https://www.makhillpublications.co/view-article/1680-5593/10.36478/makjava.2024.2.1.5