Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
Abstract
Carmustine (BCNU) is an alkylating agent used as an antineoplastic agent. A major problem with the clinical use of BCNU is the occurrence of pulmonary toxicity. Quercetin (QUE) is an important polyphenolic flavonoid that exhibits antioxidant, anti‐inflammatory and other health‐promoting effects. This study aimed to investigate the protective effect of QUE on BCNU‐induced lung injury in rats using histologic and biochemical methods. Forty adult male albino rats were divided into 4 groups: Group I served as the control group. Group received QUE orally in a dose of 100 mg/kg per day for 7 days. GroupI received a single dose (30 mg/kg) of BCNU intraperitoneally (i.p.) on the 7th day of the study. Group V received (BCNU+QUE). On the 8th day of the experiment, lung tissues were collected for histopathological examinations. The levels of malondialdehyde (MDA), hydroxyproline (HYP), myeloperoxidase (MPO), reduced glutathione (GSH), glutathione peroxidase (GSH‐Px), and superoxide dismutase (SOD) were also determined in all dissected tissues. Pretreatment with QUE ameliorated lung morphological changes noticed in the BCNU group and the levels of MDA, HYP, and MPO were significantly decreased whereas those of GSH, GSH‐Px and SOD were significantly increased. QUE provides a protective effect against BCNU‐induced lung injury by reducing oxidative stress and pulmonary fibrosis.
How to cite this article:
Marwa Sayed Badawi. Protective Effect of Quercetin on Carmustine: Induced Lung Toxicity in Adult Male Albino Rats.
DOI: https://doi.org/10.36478/10.36478/makjava.2024.1.8
URL: https://www.makhillpublications.co/view-article/1680-5593/10.36478/makjava.2024.1.8