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Research Journal of Pharmacology

ISSN: Online 1993-6019
ISSN: Print 1815-9362
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Effect of Perinatal Amphetamine Administration on Behavior and Amine Concentration in Brains of Rat Pups

A.M. Ahmed , O.S.A. Mohamed , S.E.M. Barakat , M.H. Al-Nazawi and A.M. Homeida
Page: 43-46 | Received 21 Sep 2022, Published online: 21 Sep 2022

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https://doi.org/10.36478/rjpharm.2008.43.46

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Abstract

Daily intraperitoneal administration of d-amphetamine sulphate at a dose of 8 mg kg 1 body weight to rats during 6-15 days of gestation has resulted in significant effect on sensory and motor reflexes of their pups. These pups have shown increased righting and rotating reflexes and cliff avoidance activity. Significant increase in brain noradernaline, 5-hydroxytryptamine and decrease in monoamine oxidase activity was observed in these pups and their mothers compared to their control counterparts.

How to cite this article:

A.M. Ahmed , O.S.A. Mohamed , S.E.M. Barakat , M.H. Al-Nazawi and A.M. Homeida . Effect of Perinatal Amphetamine Administration on Behavior and Amine Concentration in Brains of Rat Pups.
DOI: https://doi.org/10.36478/rjpharm.2008.43.46
URL: https://www.makhillpublications.co/view-article/1815-9362/rjpharm.2008.43.46