Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
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Evaluation of Effectiveness of Hypolipidemic Activity of Ethanolic Extract of High Dose 400 mg kg-1 of Leaves of Moringa concanensis Nimmo in Guinea Pigs
Archana Patel, Prashant M. Parmar and Viren Naik
Page: 5-13 | Received 03 Jan 2023, Published online: 28 Mar 2023
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Abstract
Hyperlipidaemia is an essential hazard aspect with inside the improvement of atherosclerosis and coronary heart disease. The significance of hyperlipidemia, particularly high levels of low‐density lipoprotein cholesterol in the blood, has been recognized as a contributing factor to cardiovascular disease. Herbal products contain numerous active phytochemical compounds that have demonstrated their beneficial impact on cardiovascular disease through their ability to lower lipid levels. In India, the roots of Moringa concanensis are traditionally employed as a remedy for obesity and hyperlipidemia. To assess the hypolipidemic activity of high‐doseethanolic extract of leaves of Moringa concanensis nimmoin guinea pigs. Eight groups of total 48 guinea pigs, of either gender, were created at random. Feeding cholesterol powder (500 mg kg-1) for 60 days caused hyperlipidaemia. As an active control group, rosuvastatin 1.5 mg kg-1 was used. The LMC was administered at a dose of 400 mg kg-1 every day for 30 days to the preventative and curative groups, for durations of 0‐30 days and 31‐60 days, respectively. For 30 days, distilled water and a typical food were provided to the control group. By using serological and histological parameters, the ethanolic extract of LMC was evaluated for its therapeutic and preventative effects. The introduction of cholesterol led to increased lipid levels, liver enzyme levels and observable changes in the liver and thoracic aorta tissues. However, when compared to the group that did not receive any treatment, both the preventive and therapeutic administration of a 400 mg kg-1 ethanolic extract of LMC exhibited a significant reduction in lipid levels (p<0.005) and contributed to the restoration of the normal histological structure of the liver and thoracic aorta. Due to its antioxidant properties, the ethanolic extract of LMC at a dosage of 400 mg kg-1 demonstrates the ability to reduce lipid levels, making it a potential treatment and preventive measure for dyslipidemia.
How to cite this article:
Archana Patel, Prashant M. Parmar and Viren Naik. Evaluation of Effectiveness of Hypolipidemic Activity of Ethanolic Extract of High Dose
400 mg kg-1 of Leaves of Moringa concanensis Nimmo in Guinea Pigs.
DOI: https://doi.org/10.36478/10.59218/makrjp.2023.5.13
URL: https://www.makhillpublications.co/view-article/1815-9362/10.59218/makrjp.2023.5.13