Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
We calculate the serum levels of 25 hydroxyvitamin D (25(OH)D) in patients who have been admitted to a rural hospital's paediatric ward due to acute respiratory tract infections (ARTI). We also determine the serum 25 hydroxyvitamin D [25(OH)D] levels in these patients in order to investigate the relationship between vitamin D insufficiency and respiratory tract infections. The patients were randomized into two groups (Groups A and B) using a computer‐generated sequence: Group A (Vitamin D 120,000 IU with standard treatment., n=165) and Group B (placebo with standard treatment., n=153). The pharmacologist, who was not involved in the study, dispensed the identical containers (Abbott Healthcare Pvt. Ltd., India) containing Vitamin D and placebo to assigned random groups. Data regarding demographics, clinical history of patients, socioeconomic status of parents, clinical presentations and medication details were recorded in a predesigned pro forma. Out of 318 (n=165 in Group A and n=153 in Group B) patients, 200 (62.8%) were males and 118 (37.1%) were females with mean age and mean weight of 36±17.7 versus 37.2±16.4 months and 13.2±4.5 versus12.5±4.1 kg, respectively and no significant difference was found (P>0.05) between them. Majority (77., 26.2%) of the patients were in the age group of 11‐20 months. Furthermore, a trend of gradual decrease in the number of ARTI patients was observed with the progression of age till 40 months of age. We draw the conclusion that vitamin D insufficiency and respiratory tract infections are related based on the findings of this study. Measuring the levels of vitamin D before beginning any supplementation is advised, as only a small number of patients had dangerous amounts of the vitamin. As a result, vitamin D treatment may not be recommended in every instance of ARTI.
How to cite this article:
Megha R. Raju and R.V. Mookambika. The Role of Vitamin D Supplementation in the Prevention of Acute Respiratory Infections: A Double‐Blind Randomized Controlled Trial.
DOI: https://doi.org/10.36478/10.36478/makrjp.2024.3.13.17
URL: https://www.makhillpublications.co/view-article/1815-9362/10.36478/makrjp.2024.3.13.17