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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Cardioprotective Effects of HMG-Co-A Reductase Inhibitors: Role of the Mechanisms of Preconditioning

Tatyana A. Denysiuk, Lev N. Sernov, Vladimir D. Lutsenko, Oleg U. Shiryaev, Andrey A. Shaposhnikov, Mikhail V. Pokrovsky, Tatyana G. Pokrovskaya, Mikhail V. Korokin and Oleg S. Gudyrev
Page: 245-248 | Received 21 Sep 2022, Published online: 21 Sep 2022

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Abstract

Statins exhibit dose-dependent cardioprotective effect in the simulation of coronary occlusion infarction in rats. In the implementation of cardioprotective effects mechanisms of pharmacological preconditioning have an essential value as evidenced by removal of the effects during blockade of K+-ATP channels with glibenclamide and blockade of iNOS with aminoguanidine.


How to cite this article:

Tatyana A. Denysiuk, Lev N. Sernov, Vladimir D. Lutsenko, Oleg U. Shiryaev, Andrey A. Shaposhnikov, Mikhail V. Pokrovsky, Tatyana G. Pokrovskaya, Mikhail V. Korokin and Oleg S. Gudyrev. Cardioprotective Effects of HMG-Co-A Reductase Inhibitors: Role of the Mechanisms of Preconditioning.
DOI: https://doi.org/10.36478/rjmsci.2015.245.248
URL: https://www.makhillpublications.co/view-article/1815-9346/rjmsci.2015.245.248