Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Sarcopenia and osteoporosis frequently coexist in postmenopausal women, collectively elevating the risk of fragility fractures. Assessing both bone and muscle health parameters may enhance fracture risk stratification beyond traditional BMD‐based evaluation. To assess the prevalence and interaction of sarcopenia and osteoporosis in postmenopausal women and evaluate the predictive performance of DXA‐derived indices, functional measures and FRAX tool for fragility fractures. This cross‐sectional study included 120 postmenopausal women at Saraswati Institute of Medical Science, Unnao (2015‐2016). Participants underwent dual‐energy X‐ray absorptiometry (DXA) for BMD and trabecular bone score (TBS) and were evaluated for muscle mass, grip strength, and gait speed. Sarcopenia was classified using EWGSOP2 criteria. FRAX scores were calculated with and without BMD. ROC and logistic regression analyses were used to evaluate fracture predictors. Osteopenia and osteoporosis were present in 35.0% and 25.0% of participants, respectively. Probable, confirmed and severe sarcopenia were seen in 18.3%, 15.0% and 9.2% of participants, respectively. FRAX‐MOF and grip strength demonstrated the highest AUCs (0.85 and 0.81, respectively) for fracture prediction. Multivariate analysis identified FRAX‐MOF and grip strength as independent predictors. TBS showed moderate correlation with both BMD and FRAX. An integrated assessment combining functional and skeletal indices enhances fragility fracture risk prediction in postmenopausal women. Sarcopenia should be considered alongside osteoporosis in routine DXA‐based assessments to better identify at‐risk individuals.
How to cite this article:
Ayush Agarwal and Saurabh Agarwal. Sarcopenia and Osteoporosis in Postmenopausal Women: A Cross‐sectional Study Assessing the Muscle‐Bone Interaction Using DXA‐Derived Indices and Functional.
DOI: https://doi.org/10.36478/makrjms.2016.6.747.752
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2016.6.747.752